Article

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality

2026-01-02

Abstract excerpt

<h4>Summary</h4> Research on progeria not only contributes to treatments for the disease but also enhances our understanding of physiological ageing 1 . Mouse models of progeria recapitulate pathological ageing phenotypes seen in patients, including cardiovascular defects, increased cellular senescence, systemic inflammation, DNA damage accumulation, and shortened lifespan 2 . In cultured cells from Hutchinson-...

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Literature Corpus work: 61fd4a73-95e8-562a-8465-bf6012cde34f
DOI: 10.64898/2025.12.31.697195

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