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Unveiling senescence-associated secretory phenotype in epidermal aging: insights from reversibly immortalized keratinocytes

23 Sept 2024

Abstract excerpt

Aging of epidermal keratinocytes profoundly impacts skin health, contributing to changes in appearance, barrier function, and susceptibility to diseases. Despite its significance, the molecular mechanisms underlying epidermal aging remain elusive. In this study, a reversible immortalized cell line was established by expressing SV40T in keratinocytes using the Tet-Off lentiviral system. Inducing a senescent...

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PMID: 39316420
DOI: 10.18632/aging.206117

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