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Article

Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Cell death & disease - 15 May 2014

Lu H, Fang E F, Sykora P, Kulikowicz T, Zhang Y, Becker K G, Croteau D L, Bohr V A

Abstract excerpt

Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process thought to contribute to aging-related degeneration and disease. Deficiency of RecQ helicase RECQL4 leads to Rothmund-Thomson syndrome (RTS), and we have investigated whether senescence is involved using cellular approaches and a mouse model. We first systematically investigated whether depletion of RECQL4 and the...

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Source

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Identifiers

PMID: 24832598
DOI: 10.1038/cddis.2014.168
PMCID: PMC4047874

Genes

RECQL4
BLM
RECQL5
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.PMID 24832598Read ↗

Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.Semantic proximity Read ↗

RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integritySemantic proximity Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

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Human RecQ Helicases in DNA Double-Strand Break RepairSemantic proximity Read ↗

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Semantic proximity Read ↗

The involvement of human RECQL4 in DNA double‐strand break repairSemantic proximity Read ↗

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.Semantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replicationSemantic proximity Read ↗

RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.Semantic proximity Read ↗

The versatile RECQL4.Semantic proximity Read ↗

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.Semantic proximity Read ↗

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