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Article

Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription.

Nucleic acids research - 19 Jun 2020

Shao Wei, Ding Zhan, Zheng Zeng-Zhang, Shen Ji-Jia, Shen Yu-Xian, Pu Jia, Fan Yu-Jie, Query Charles C, Xu Yong-Zhen

Abstract excerpt

Transcription and pre-mRNA splicing are coupled to promote gene expression and regulation. However, mechanisms by which transcription and splicing influence each other are still under investigation. The ATPase Prp5p is required for pre-spliceosome assembly and splicing proofreading at the branch-point region. From an open UV mutagenesis screen for genetic suppressors of prp5 defects and subsequent targeted...

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Identifiers

PMID: 32399566
DOI: 10.1093/nar/gkaa311
PMCID: PMC7293005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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