Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.

doi:10.1093/genetics/136.3.833

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Article

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.

Genetics - 1 Mar 1994

Maddock J R, Weidenhammer E M, Adams C C, Lunz R L, Woolford J L

Abstract excerpt

The PRP4 gene encodes a protein that is a component of the U4/U6 small nuclear ribonucleoprotein particle and is necessary for both spliceosome assembly and pre-mRNA splicing. To identify genes whose products interact with the PRP4 gene or gene product, we isolated second-site suppressors of temp...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cold Temperature
DNA Primers
DNA, Fungal
Fungal Proteins
Genes, Fungal
Genes, Lethal
Genes, Regulator
Genes, Suppressor
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Linkage

Models, Genetic

Molecular Sequence Data

Mutation

Phenotype

Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 8005438
DOI: 10.1093/genetics/136.3.833
PMCID: PMC1205889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8005438-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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