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Article

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.

Genetics - 1 Mar 1994

Maddock J R, Weidenhammer E M, Adams C C, Lunz R L, Woolford J L

Abstract excerpt

The PRP4 gene encodes a protein that is a component of the U4/U6 small nuclear ribonucleoprotein particle and is necessary for both spliceosome assembly and pre-mRNA splicing. To identify genes whose products interact with the PRP4 gene or gene product, we isolated second-site suppressors of temperature-sensitive prp4 mutations. We limited ourselves to suppressors with a distinct phenotype, cold sensitivity, to...

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Identifiers

PMID: 8005438
DOI: 10.1093/genetics/136.3.833
PMCID: PMC1205889

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