Article
A novel role for a U5 snRNP protein in 3' splice site selection.
Genes & development - 1 Apr 1995
Umen J G, Guthrie C
Abstract excerpt
The choice of a 3' splice site in Saccharomyces cerevisiae introns involves recognition of a uridine-rich tract upstream of the AG dinucleotide splice junction. By isolating mutants that eliminate the normal preference for uridine-containing 3' splice sites in a cis-competition, we identified a mutation that is an allele of PRP8, prp8-101. This was unexpected because previous analysis has demonstrated that the U5...
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