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Article

A novel role for a U5 snRNP protein in 3' splice site selection.

Genes & development - 1 Apr 1995

Umen J G, Guthrie C

Abstract excerpt

The choice of a 3' splice site in Saccharomyces cerevisiae introns involves recognition of a uridine-rich tract upstream of the AG dinucleotide splice junction. By isolating mutants that eliminate the normal preference for uridine-containing 3' splice sites in a cis-competition, we identified a m...

Topics

Actins
Alleles
Base Sequence
DNA Primers
Fungal Proteins
Introns
Molecular Sequence Data
Mutation
Phenotype
RNA
RNA Splicing
Ribonucleoprotein, U4-U6 Small Nuclear
Ribonucleoprotein, U5 Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Tubulin

Uridine

Source

Identifiers

PMID: 7535718
DOI: 10.1101/gad.9.7.855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7535718-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A novel role for a U5 snRNP protein in 3' splice site selection.PMID 7535718Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

Control of 3' splice site selection in S. cerevisiae by a highly conserved amino acid within the Prp8 α-finger domain.Semantic proximity Read ↗

Control of 3’ Splice Site Selection in <i>S. cerevisiae</i> by a Highly Conserved Amino Acid within the Prp8 α-finger DomainSemantic proximity Read ↗

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Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants.Semantic proximity Read ↗

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