Article

Profiling the kinome in oncogenic RAS mutant cells

2020-01-01

Abstract excerpt

RAS Proteins (KRAS4A, KRAS4B, NRAS and HRAS) are small GTPases involved in normal cellular proliferation, differentiation and apoptosis. Mutations in RAS, rendering it in the active GTP-bound state, are present in around 20% of human cancers, making it the subject of many years intensive research. Despite this, there has been limited success in targeting the RAS pathway due to the complex nature of RAS biology. St...

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Literature Corpus work: 32b72cf0-c3f1-5171-8530-42b6a5eb4aaa
DOI: 10.17638/03119910

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