Article

A cancer-associated K-RAS mutant that preferentially binds GDP displays gain-of-function and atypical signaling

2022-04-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The RAS genes, which are the prototype for the RAS superfamily of small GTPases, encode guanine nucleotide binding proteins that are frequently mutated in cancer. The superfamily has five major branches: RAS, RHO, RAB, RAN, and ARF. Its wild type members function as molecular switches that are active when GTP-bound and inactive when GDP-bound. Previously analyze...

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Literature Corpus work: 3a1c35bb-43fb-5371-bf45-65654d4dad31
DOI: 10.21203/rs.3.rs-1521657/v1

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