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Atypical Exon 2/3 Mutants G48C, Q43K, and E37K Present Oncogenic Phenotypes Distinct from Characterized NRAS Variants.

Cells - 12 Oct 2024

Fran Mark Anthony G, Leaño Dominique Mickai G, de Borja James Allen D, Uy Charles John T, Andresan Aleq Adrianne R, Sacdalan Dennis L, Garcia Reynaldo L

Abstract excerpt

NRAS belongs to the RAS family of GTPases. In colorectal cancer (CRC), NRAS mutations are rare compared to KRAS, but may lead to worse outcomes. We report the functional characterization of the novel NRAS mutants-G48C, Q43K, and E37K-identified in Filipino young-onset CRC patients. Unlike previously characterized NRAS mutants with no apparent effects on cell proliferation, these mutants enhanced proliferation of...

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PMID: 39451209
DOI: 10.3390/cells13201691
PMCID: PMC11506670

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