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Article

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

European journal of cell biology - 1 Jun 2024

Gebregiworgis Teklab, Chan Jonathan Yui-Lai, Kuntz Douglas A, Privé Gilbert G, Marshall Christopher B, Ikura Mitsuhiko

Abstract excerpt

The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isoform and mutation-specific investigations have produced successful RAS inhibitors that are either specific to certain mutants, isoforms (pan-KRAS) or target all RAS...

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PMID: 38640594
DOI: 10.1016/j.ejcb.2024.151414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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