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The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

14 Nov 2022

Abstract excerpt

The human SMC5/6 complex is a conserved guardian of genome stability and an emerging component of antiviral responses. These disparate functions likely require distinct mechanisms of SMC5/6 regulation. In yeast, Smc5/6 is regulated by its Nse5/6 subunits, but such regulatory subunits for human SMC5/6 are poorly defined. Here, we identify a novel SMC5/6 subunit called SIMC1 that contains SUMO interacting motifs...

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PMID: 36373674
DOI: 10.7554/elife.79676

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