Article
Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?
Neurobiology of aging - 1 Aug 2020
Yassine Hussein N, Anderson Andrea, Brinton Roberta, Carmichael Owen, Espeland Mark A, Hoscheidt Siobhan, Hugenschmidt Christina E, Keller Jeffrey N, Peters Anne, Pi-Sunyer Xavier
Abstract excerpt
In the Look AHEAD trial, randomization to Intensive Lifestyle Intervention (ILI) or Diabetes Support and Education (DSE) did not result in differences in cognitive outcomes. However, menopause and APOE genotype are factors that affect the response to this intervention. The effect of this intervention on a single cognitive assessment was examined in 3 groups of women: premenopausal or <5 years postmenopausal (N =...
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