Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.

doi:10.1186/s12937-024-00966-w

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Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.

Nutrition journal - 12 Jun 2024

Soldevila-Domenech Natalia, Fagundo Beatriz, Cuenca-Royo Aida, Forcano Laura, Gomis-González Maria, Boronat Anna, Pastor Antoni, Castañer Olga, Zomeño Maria Dolores, Goday Albert, Dierssen Mara, Baghizadeh Hosseini Khashayar, Ros Emilio, Corella Dolores, Martínez-González Miguel Ángel, Salas-Salvadó Jordi, Fernández-Aranda Fernando, Fitó Montserrat, de la Torre Rafael

Abstract excerpt

BACKGROUND: The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) and N-acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved in multiple neurological disorders and metabolic processes. Hypothesizing that eCBs and NAEs will be biomarkers of a MedDiet intervention and will...

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PMID: 38862960
DOI: 10.1186/s12937-024-00966-w
PMCID: PMC11167771

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