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A combination of midlife diabetes mellitus and the apolipoprotein E ε4 allele increase risk for cognitive decline

17 Nov 2022

Abstract excerpt

Background: It has been suggested that diabetes mellitus (DM) and the apolipoprotein E (APOE) ε4 allele (APOE4) increase the risk for Alzheimer's disease (AD) and cognitive decline. However, the evidence is sparse. We explored whether APOE4 status modulated the effects of midlife and late-life DM on global cognition of non-demented older adults. Methods: In all, 176 non-demented adults (age 65-90 years) were...

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PMID: 36466611
DOI: 10.3389/fnagi.2022.1065117

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