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Article

Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.

The journals of gerontology. Series A, Biological sciences and medical sciences - 16 Jan 2025

Dunk Michelle M, Driscoll Ira, Espeland Mark A, Hayden Kathleen M, Liu Simin, Nassir Rami, Natale Ginny, Shadyab Aladdin H, Manson JoAnn E

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ε4 allele, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) are well-established risk factors for dementia. Relationships between APOE and incidence of T2DM and CVD are not fully understood but may shed light on the mechanisms underlying dementia pathogenesis. METHODS: Postmenopausal women (N = 6 795) from the Women's Health Initiative hormone therapy...

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Identifiers

PMID: 39364911
DOI: 10.1093/gerona/glae246
PMCID: PMC11775828

Genes

APOE

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