Article

Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes Study

2026-08-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Metformin may influence risk of dementia, with prior conflicting observations of protection or harm. <h4>Objective</h4> To determine the association of randomization to metformin vs. placebo or intensive lifestyle intervention (ILS) in the Diabetes Prevention Program (DPP) with cognitive outcomes (cognitive impairment syndromes and trajectories of cognitive test performance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f8e0091-2dc1-5ebe-8254-eb4a31811b76
DOI: 10.64898/2026.08.05.26359234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes StudyDOI 10.64898/2026.08.05.26359234Read

Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study.Semantic proximity Read

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomization studySemantic proximity Read

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomisation studySemantic proximity Read

Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status.Semantic proximity Read

Clinical modifiers of the association between type 1 diabetes and dementia incidenceSemantic proximity Read

A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose IntoleranceSemantic proximity Read

Type 2 Diabetes and Cognitive Status in the Health and Retirement Study: A Mendelian Randomization ApproachSemantic proximity Read

The association between type 2 diabetes disease trajectories and dementia incidenceSemantic proximity Read

Drug repurposing of metformin for Alzheimer’s disease: Combining causal inference in medical records data and systems pharmacology for biomarker identificationSemantic proximity Read

Age at Diabetes Diagnosis and Cognitive Function Among Older Adults in the China Health and Retirement Longitudinal Study, 2011–2018Semantic proximity Read

Eight-Year Longitudinal Associations of the Onset of Prediabetes and Diabetes with Cognitive Function Decline Among Chinese Adults Aged 45 Years or OlderSemantic proximity Read

Mendelian randomization study of diabetes and dementia in the Million Veteran ProgramSemantic proximity Read