Article
Apolipoprotein E and Its Association With Cognitive Change and Modification of Treatment Effects of Vitamin D3 and Omega-3s on Cognitive Change: Results From the In-Clinic Subset of a Randomized Clinical Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2024
Vyas Chirag M, Kang Jae H, Mischoulon David, Cook Nancy R, Reynolds Iii Charles F, Chang Grace, Mora Samia, De Vivo Immaculata, Manson JoAnn E, Okereke Olivia I
Abstract excerpt
BACKGROUND: Apolipoprotein E (APOE)-ε4 allele is associated with cognitive decline; however, its potential to modify effects of vitamin D3 and omega-3s supplementation on later-life cognition is unclear. Our objectives were to estimate among the in-clinic subset of a randomized trial: (1) associations between APOE-ε4 and global and domain-specific cognitive change, with exploration of potential sex and race...
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