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Article

Differential effects of SNARE-dependent gliotransmission on behavioral phenotypes in a mouse model of Huntington's disease.

Experimental neurology - 1 Aug 2020

King Annesha C, Wood Tara E, Rodriguez Efrain, Parpura Vladimir, Gray Michelle

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the widely expressed huntingtin protein. Multiple studies have indicated the importance of mutant huntingtin (mHTT) in astrocytes to HD pathogenesis. Astrocytes exhibit SNARE-dependent exocytosis and gliotransmission, which can be hampered by transgenic expression of dominant negative SNARE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32387649
DOI: 10.1016/j.expneurol.2020.113358
PMCID: PMC7313419

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