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Article

αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.

Human molecular genetics - 1 May 2016

Oliveira Ana Osório, Osmand Alexander, Outeiro Tiago Fleming, Muchowski Paul Joseph, Finkbeiner Steven

Abstract excerpt

Huntington's disease (HD) is caused by an expanded polyglutamine (polyQ) tract in the huntingtin (htt) protein. The polyQ expansion increases the propensity of htt to aggregate and accumulate, and manipulations that mitigate protein misfolding or facilitate the clearance of misfolded proteins are predicted to slow disease progression in HD models. αB-crystallin (αBc) or HspB5 is a well-characterized member of the...

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Identifiers

PMID: 26920069
DOI: 10.1093/hmg/ddw028
PMCID: PMC4986324

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