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Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors

1 Jan 2023

Abstract excerpt

Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts, including in striatal neurons and astrocytes. It is unknown whether pathophysiology in vivo can be attenuated by lowering mHTT in either cell type throughout the brain, and the relative contributions of neurons and astrocytes to HD...

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PMID: 36640336
DOI: 10.1016/j.celrep.2022.111953

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