Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H4 variant, H4G, drives ribosomal RNA transcription and breast cancer cell proliferation by loosening nucleolar chromatin structure.

Journal of cellular physiology - 1 Dec 2020

Pang Matthew Y H, Sun Xulun, Ausió Juan, Ishibashi Toyotaka

Abstract excerpt

The hominidae-specific histone variant H4G is expressed in breast cancer patients in a stage-dependent manner. H4G localizes primarily in the nucleoli via its interaction with nucleophosmin (NPM1). H4G is involved in rDNA transcription and ribosome biogenesis, which facilitates breast cancer cell proliferation. However, the molecular mechanism underlying this process remains unknown. Here, we show that H4G is not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleolus
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Gene Expression Regulation, Neoplastic

Share to Histones

Share to Nucleophosmin

Share to Nucleosomes

Share to RNA, Ribosomal

Source

Identifiers

PMID: 32385931
DOI: 10.1002/jcp.29770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H4 variant, H4G, drives ribosomal RNA transcription and breast cancer cell proliferation by loosening nucleolar chromatin structure.PMID 32385931Read ↗

A novel histone H4 variant regulates rDNA transcription in breast cancerSemantic proximity Read ↗

H2A.B is a cancer/testis factor involved in activation of ribosome biogenesis in Hodgkin LymphomaSemantic proximity Read ↗

Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce epithelial-to-mesenchymal transition in breast cancerSemantic proximity Read ↗

Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presenceSemantic proximity Read ↗

Novel classes and evolutionary turnover of histone H2B variants in the mammalian germlineSemantic proximity Read ↗

Short Histone H2A Variants: Small in Stature but not in Function.Semantic proximity Read ↗

Nucleosome reorganisation in breast cancer tissuesSemantic proximity Read ↗

Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanismSemantic proximity Read ↗

Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease.Semantic proximity Read ↗

Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.Semantic proximity Read ↗

The double face of the histone variant H3.3.Semantic proximity Read ↗

Nucleolar Adaptation in Human CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.