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Article

Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease.

International journal of molecular sciences - 11 Jan 2023

Kumar Ashok, Maurya Preeti, Hayes Jeffrey J

Abstract excerpt

Linker histones (LH) are a critical component of chromatin in addition to the canonical histones (H2A, H2B, H3, and H4). In humans, 11 subtypes (7 somatic and 4 germinal) of linker histones have been identified, and their diverse cellular functions in chromatin structure, DNA replication, DNA repair, transcription, and apoptosis have been explored, especially for the somatic subtypes. Delineating the unique role...

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Identifiers

PMID: 36674981
DOI: 10.3390/ijms24021463
PMCID: PMC9860689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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