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Article

Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2020

Zeyen Thomas, Noristani Rozina, Habib Shahin, Heinisch Ole, Slowik Alexander, Huber Michael, Schulz Jörg B, Reich Arno, Habib Pardes

Abstract excerpt

Transforming growth factor-β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain injury. TAK1 acts as a key regulator of NF-ΚB and the MAP kinases JNK and p38 and modulates post-ischemic neuroinflammation and apoptosis. Microglia are the main TAK1-expressing immunocompetent cells of the brain. However, little is known about the function and regulation of...

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Identifiers

PMID: 32382778
DOI: 10.1007/s00109-020-01916-9
PMCID: PMC7297861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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