Article

Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity

2024-01-01

Abstract excerpt

Ischemic stroke is a sudden and acute disease characterized by neuronal death, glia activation, and a severe inflammatory process. Neuroinflammation is an early event after cerebral ischemia, with microglia playing a leading role. Microglial activation involves functional and morphological changes that drive a wide variety of phenotypes. In this context, deciphering the molecular mechanisms underlying such microgl...

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Literature Corpus work: b959f64c-5859-5532-95c9-0ad415a6e9de
DOI: 10.1101/2023.12.31.571469

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