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Article

Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Mar 2007

Lalancette-Hébert Mélanie, Gowing Geneviève, Simard Alain, Weng Yuan Cheng, Kriz Jasna

Abstract excerpt

Here we report in vivo evidence of a neuroprotective role of proliferating microglial cells in cerebral ischemia. Using transgenic mice expressing a mutant thymidine kinase form of herpes simplex virus driven by myeloid-specific CD11b promoter and ganciclovir treatment as a tool, we selectively a...

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Identifiers

PMID: 17344397
DOI: 10.1523/JNEUROSCI.5360-06.2007
PMCID: PMC6672496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17344397-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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