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Article

The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia.

PloS one - 1 Jan 2024

Ye Dan, Liu Jiamin, Lin Long, Hou Pengwei, Feng Tianshun, Wang Shousen

Abstract excerpt

The Ang-(1-7)/MasR axis is critically involved in treating several diseases; For example, Ang-(1-7) improves inflammatory response and neurological function after traumatic brain injury and inhibits post-inflammatory hypothermia. However, its function in traumatic brain injury (TBI) combined with seawater immersion hypothermia remains unclear. Here, we used a mice model of hypothermic TBI and a BV2 cell model of...

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Identifiers

PMID: 38728304
DOI: 10.1371/journal.pone.0303150
PMCID: PMC11086881

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