Article

Induction of IRG1 following ischemic stroke promotes HO-1 and BDNF expression to alleviate neuroinflammation and restrain ischemic brain injury

2020-05-26

Abstract excerpt

<title>Abstract</title> <p>Background Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate through diverting cis-aconitate away from the tricarboxylic acid cycle. The immunoregulatory effect of IRG1/itaconate axis has recently documented in LPS-activated mouse and human macrophages. In addition, dimethyl itaconate, an itaconate derivative, was r...

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Literature Corpus work: c5690f5b-b321-5e20-9e16-1b1a9a39fa19
DOI: 10.21203/rs.3.rs-27606/v1

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