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Article

SIRT1 modulates microglia phenotypes via inhibiting drp1 phosphorylation reduces neuroinflammation in heatstroke.

Brain research bulletin - 1 Nov 2024

Zhu Jie, Jin Panshi, Zhou Tingting, Zhang Dingshun, Wang Zixin, Tang Zhen, Liu Zhifeng, Ren Guangli

Abstract excerpt

BACKGROUND: Brain injury often results in high mortality rates and significant sequelae following severe heatstroke (HS). Neuroinflammation aggravates HS-induced brain injury, yet the involvement of microglia in heat-induced neuroinflammation deserves further investigation. METHODS: Our study investigated activation status, phenotype markers, production of pro-inflammatory cytokine and reactive oxygen species...

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PMID: 39396713
DOI: 10.1016/j.brainresbull.2024.111101

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