Article

Hypothermia Protects Against Ischemic Stroke Through Peroxisome-proliferator-activated-receptor Gamma

2021-08-03

Abstract excerpt

<h4>Background: </h4> IS (ischemic stroke) remains to be a global public health burden and urgently demands novel strategies. Hypothermia plays a beneficial role in central nervous system diseases. However, the function of hypothermia in IS has not been elucidated. Here we demonstrated the role of hypothermia in IS and explore the mechanism. <h4>Methods: </h4>: IS phenotype was detected by infarct size and infarct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93297836-89ec-5cff-bd12-d6330ecb7992
DOI: 10.21203/rs.3.rs-754337/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypothermia Protects Against Ischemic Stroke Through Peroxisome-proliferator-activated-receptor GammaDOI 10.21203/rs.3.rs-754337/v1Read

Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke.Semantic proximity Read

Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway.Semantic proximity Read

The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia.Semantic proximity Read

CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway.Semantic proximity Read

Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injurySemantic proximity Read

Inflammation-mediated damage as a potential therapeutic target in acute ischemic stroke.Semantic proximity Read

Effects of therapeutic hypothermia on the glial proteome and phenotype.Semantic proximity Read

The Impact of Environmental Enrichment on Neurological Damage: Mechanistic Study of Ferroptosis Inhibition via Tlr4Semantic proximity Read

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia.Semantic proximity Read

MFG-E8 attenuates neuro-inflammation in subarachnoid hemorrhage through driving microglial M2 polarization via modulating Integrin β3/SOCS3/STAT3 signaling pathwaySemantic proximity Read

Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes.Semantic proximity Read

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.Semantic proximity Read