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Article

Inhibition of Mer exacerbates early brain injury by regulating microglia/macrophage phenotype after subarachnoid hemorrhage in mice.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Sept 2022

Tan Xiaoxiao, Zheng Yonghe, Zeng Hanhai, Peng Yucong, Yu Xiaobo, Cao Shenglong

Abstract excerpt

BACKGROUND: Polarization of microglia/macrophages toward the pro-inflammatory phenotype is a crucial contributor to neuroinflammation after subarachnoid hemorrhage (SAH). Mer belongs to the TAM receptor tyrosine kinases family, which is known to play a significant role in the resolution of inflammation. However, the effect and mechanism of Mer after SAH remain unclear. In this study, we explored the effect of Mer...

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Identifiers

PMID: 35901587
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106659

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