Article

Inhibition of histone deacetylase 1 or 2 reduces microglia activation through a gene expression independent mechanism

2017-02-10

Abstract excerpt

Histone deacetylase (HDAC) inhibitors prevent neural cell death in in vivo models of cerebral ischaemia, brain injury and neurodegenerative disease. One mechanism by which HDAC inhibitors may do this is by suppressing the excessive inflammatory response of chronically activated microglia. However, the molecular mechanisms underlying this anti-inflammatory effect and the specific HDAC responsible are not fully und...

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Literature Corpus work: abac64fa-e885-51af-91b8-5361b00407b1
DOI: 10.1101/107649

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