Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

Abstract excerpt

Background Whether inflammation is independently associated with development of JAK2 V617F mutation and myeloproliferative neoplasm is not clear. We tested the hypothesis that a loss-of-function polymorphism in IL6R (marked by rs4537545) reduces risk of JAK2 V617F mutation and myeloproliferative neoplasm in a Mendelian randomization study. Methods We genotyped 107,969 Danes from the Copenhagen General Population...

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