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Leveraging genetic data to investigate the effects of interleukin‐6 receptor signalling on levels of 40 circulating cytokines

10 Sept 2021

Abstract excerpt

Interleukin 6 (IL-6) is a circulating cytokine implicated in inflammatory processes. However, the broad effects of IL-6 receptor (IL-6R) signalling on other circulating cytokines is not known. Using summary-level data from genome-wide association studies, we leveraged genetic variants that proxy IL-6R signalling in two-sample Mendelian randomization analyses to investigate effects on levels of 40 circulating...

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PMID: 34506050
DOI: 10.1111/bcp.15079

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