Article
Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.
Blood cancer journal - 16 Jul 2020
Sánchez-Maldonado J M, Campa D, Springer J, Badiola J, Niazi Y, Moñiz-Díez A, Hernández-Mohedo F, González-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, López-Nevot M A, Fianchi L, Pagano L, López-Fernández E, Potenza L, Luppi M, Moratalla L, Rodríguez-Sevilla J J, Fonseca J E, Tormo M, Solano C, Clavero E, Romero A, Li Y, Lass-Flörl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M G, Gsur A, Dumontet C, Canzian F, Försti A, Jurado M, Sainz J
Abstract excerpt
The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of...
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