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Article

Mendelian randomization study on causal association of IL-6 signaling with pulmonary arterial hypertension

5 Mar 2023

Abstract excerpt

Background A recent Mendelian randomization (MR) did not support an effect of the lead interleukin-6 receptor (IL-6 R) variant on risk of pulmonary arterial hypertension (PAH). Thus, we used two sets of genetic instrumental variants (IVs) and publicly available PAH genome-wide association studies (GWAS) to reassess the genetic causal link between IL-6 signaling and PAH.Methods Six independent IL-6 signaling and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36871578
DOI: 10.1080/10641963.2023.2183963

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