Genomic Evolution of Breast Cancer Metastasis and Relapse.

doi:10.1016/j.ccell.2017.07.005

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Genomic Evolution of Breast Cancer Metastasis and Relapse.

Cancer cell - 14 Aug 2017

Yates Lucy R, Knappskog Stian, Wedge David, Farmery James H R, Gonzalez Santiago, Martincorena Inigo, Alexandrov Ludmil B, Van Loo Peter, Haugland Hans Kristian, Lilleng Peer Kaare, Gundem Gunes, Gerstung Moritz, Pappaemmanuil Elli, Gazinska Patrycja, Bhosle Shriram G, Jones David, Raine Keiran, Mudie Laura, Latimer Calli, Sawyer Elinor, Desmedt Christine, Sotiriou Christos, Stratton Michael R, Sieuwerts Anieta M, Lynch Andy G, Martens John W, Richardson Andrea L, Tutt Andrew, Lønning Per Eystein, Campbell Peter J

Abstract excerpt

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late...

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Identifiers

PMID: 28810143
DOI: 10.1016/j.ccell.2017.07.005
PMCID: PMC5559645

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JAK2
STAT3

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