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Article

Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets.

The Journal of clinical investigation - 3 Aug 2020

Paul Matt R, Pan Tien-Chi, Pant Dhruv K, Shih Natalie Nc, Chen Yan, Harvey Kyra L, Solomon Aaron, Lieberman David, Morrissette Jennifer Jd, Soucier-Ernst Danielle, Goodman Noah G, Stavropoulos S William, Maxwell Kara N, Clark Candace, Belka George K, Feldman Michael, DeMichele Angela, Chodosh Lewis A

Abstract excerpt

Nearly all breast cancer deaths result from metastatic disease. Despite this, the genomic events that drive metastatic recurrence are poorly understood. We performed whole-exome and shallow whole-genome sequencing to identify genes and pathways preferentially mutated or copy-number altered in metastases compared with the paired primary tumors from which they arose. Seven genes were preferentially mutated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32657779
DOI: 10.1172/JCI129941
PMCID: PMC7410083

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