Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver tropism of ER mutant breast cancer is characterized by unique molecular changes and immune infiltration.

Breast cancer research and treatment - 1 Jun 2024

Wu Yang, Li Zheqi, Lee Adrian V, Oesterreich Steffi, Luo Bin

Abstract excerpt

PURPOSE: Hotspot estrogen receptor alpha (ER/ESR1) mutations are recognized as the driver for both endocrine resistance and metastasis in advanced ER-positive (ER+) breast cancer, but their contributions to metastatic organ tropism remain insufficiently understood. In this study, we aim to comprehensively profile the organotropic metastatic pattern for ESR1 mutant breast cancer. METHODS: The organ-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Transcriptome

Source

Identifiers

PMID: 38427312
DOI: 10.1007/s10549-024-07255-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver tropism of ER mutant breast cancer is characterized by unique molecular changes and immune infiltration.PMID 38427312Read ↗

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.Semantic proximity Read ↗

Genomic and clinical landscape of metastatic hormone receptors-positive breast cancers carrying ESR1 alterations.Semantic proximity Read ↗

Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer.Semantic proximity Read ↗

Hotspot <i>ESR1</i> mutations are multimodal and contextual drivers of breast cancer metastasisSemantic proximity Read ↗

Hormonal modulation of ESR1 mutant metastasis.Semantic proximity Read ↗

Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast CancerSemantic proximity Read ↗

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.Semantic proximity Read ↗

Molecular Divergence Shapes Lung- and Liver-Tropic Metastasis in HER2-Positive Breast CancerSemantic proximity Read ↗

Treatment Represents a Key Driver of Metastatic Cancer Evolution.Semantic proximity Read ↗

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.Semantic proximity Read ↗

ESR1 mutations are frequent in newly diagnosed metastatic and loco-regional recurrence of endocrine-treated breast cancer and carry worse prognosis.Semantic proximity Read ↗

Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.