Article
Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination.
Genome medicine - 6 Feb 2024
Lawrence-Paul Matthew R, Pan Tien-Chi, Pant Dhruv K, Shih Natalie N C, Chen Yan, Belka George K, Feldman Michael, DeMichele Angela, Chodosh Lewis A
Abstract excerpt
BACKGROUND: Evolutionary models of breast cancer progression differ on the extent to which metastatic potential is pre-encoded within primary tumors. Although metastatic recurrences often harbor putative driver mutations that are not detected in their antecedent primary tumor using standard sequencing technologies, whether these mutations were acquired before or after dissemination remains unclear. METHODS: To...
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