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Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer

15 Apr 2020

Abstract excerpt

-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. The mitochondrial sirtuin Sirt4, for a long time considered as mainly a mono-ADP-ribosyltransferase, recently has shown a robust deacylase activity in addition to the already accepted substrate-dependent lipoamidase and deacetylase properties. Through these and likely other...

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PMID: 32373514
DOI: 10.3389/fonc.2020.00474

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