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From Sirtuin Biology to Human Diseases: An Update

19 Oct 2012

Abstract excerpt

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases,...

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PMID: 23086954
DOI: 10.1074/jbc.r112.402768

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