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SIRT3: As Simple As It Seems?

25 Oct 2013

Abstract excerpt

Identification of conserved pathways regulating longevity holds out the eventual possibility of pharmacologic health- and lifespan extension in humans. Members of the sirtuin deacetylase/ADP-ribosyltransferase/deacylase family extend longevity in invertebrates and promote various aspects of mammalian healthspan. The mitochondrial sirtuin SIRT3 deacetylates numerous proteins in this organelle, regulating...

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PMID: 24192814
DOI: 10.1159/000354382

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