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Sirtuins, Metabolism, and Cancer

1 Jan 2012

Abstract excerpt

More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have been characterized, uncovering the underlying mechanisms of...

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PMID: 22363287
DOI: 10.3389/fphar.2012.00022

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