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Mitochondrial sirtuins: Energy dynamics and cancer metabolism

1 Feb 2024

Abstract excerpt

Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial sirtuins, (Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This review explores their impact on cellular processes, with a focus on the NAD+ interplay and the modulation of their enzymatic activities. The varied roles of SIRT3, SIRT4, and SIRT5 in metabolic adaptation and cancer are outlined,...

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PMID: 38331199
DOI: 10.1016/j.mocell.2024.100029

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