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Article

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease

30 Jan 2013

Abstract excerpt

SIRT3 is a NAD(+)-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses to stress, including metabolic reprogramming and enhancing antioxidant defense mechanisms. Here, we discuss the role that SIRT3 plays at both a cellular and...

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PMID: 24020003
DOI: 10.1177/1947601913476949

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