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Article

The Two-Faced Role of SIRT6 in Cancer

8 Mar 2021

Abstract excerpt

-dependent nuclear deacylase and mono-ADP-ribosylase with a wide spectrum of substrates. Through its pleiotropic activities, SIRT6 modulates either directly or indirectly key processes linked to cell fate determination and oncogenesis such as DNA damage repair, metabolic homeostasis, and apoptosis. SIRT6 regulates the expression and activity of both pro-apoptotic (e.g., Bax) and anti-apoptotic factors (e.g.,...

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PMID: 33800266
DOI: 10.3390/cancers13051156

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