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Article

Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis.

The Journal of infectious diseases - 1 Sept 2021

Chen Yiwang, Ji Lecai, Liu Qingyun, Li Jinli, Hong Chuangyue, Jiang Qi, Gan Mingyu, Takiff Howard E, Yu Weiye, Tan Weiguo, Gao Qian

Abstract excerpt

Tuberculosis heteroresistance, in which only a fraction of the bacteria in a patient with tuberculosis contains drug-resistant mutations, has been a rising concern. However, its origins and prevalence remain elusive. Here, whole-genome sequencing was performed on 83 serial isolates from 31 patients with multidrug-resistant tuberculosis, and heteroresistance was detected in isolates from 21 patients (67.74%)....

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Identifiers

PMID: 34467983
DOI: 10.1093/infdis/jiab011

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