Within-Host Heterogeneity ofMycobacterium tuberculosisInfection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

doi:10.1093/infdis/jiw014

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Article

Within-Host Heterogeneity ofMycobacterium tuberculosisInfection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

14 Jan 2016

Abstract excerpt

The clinical management of tuberculosis is a major challenge in southern Africa. The prevalence of within-host genetically heterogeneous Mycobacterium tuberculosis infection and its effect on treatment response are not well understood. We enrolled 500 patients with tuberculosis in KwaZulu-Natal and followed them through 2 months of treatment. Using mycobacterial interspersed repetitive units-variable number of...

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PMID: 26768249
DOI: 10.1093/infdis/jiw014

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