Article
Is APOE ε4 associated with cognitive performance in early MS?
Neurology(R) neuroimmunology & neuroinflammation - 1 Jul 2020
Engel Sinah, Graetz Christiane, Salmen Anke, Muthuraman Muthuraman, Toenges Gerrit, Ambrosius Björn, Bayas Antonios, Berthele Achim, Heesen Christoph, Klotz Luisa, Kümpfel Tania, Linker Ralf A, Meuth Sven G, Paul Friedemann, Stangel Martin, Tackenberg Björn, Then Bergh Florian, Tumani Hayrettin, Weber Frank, Wildemann Brigitte, Zettl Uwe K, Antony Gisela, Bittner Stefan, Groppa Sergiu, Hemmer Bernhard, Wiendl Heinz, Gold Ralf, Zipp Frauke, Lill Christina M, Luessi Felix
Abstract excerpt
OBJECTIVE: To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS). METHODS: This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE...
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