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Article

APOE ε4 is associated with exacerbation of cognitive decline in patients with multiple sclerosis.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology - 1 Sept 2011

Shi Jiong, Tu Jiang-Long, Gale Shawn D, Baxter Leslie, Vollmer Timothy L, Campagnolo Denise I, Tyry Tuula M, Zhuang Yi, Kuniyoshi Sandra M

Abstract excerpt

BACKGROUND: : In previous studies we and others have demonstrated an association with apolipoprotein (APOE) ε4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE ε4 status exacerbates progression of cognitive deficits in MS. METHODS: : A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance...

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Source

Identifiers

PMID: 21945984
DOI: 10.1097/WNN.0b013e31823380b5

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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